HISTORY

THE HISTORY OF IVY LEAF

The History of Hedera Helix

Known commonly as English ivy, Hedera helix is a climbing evergreen plant indigenous to a vast expanse of Europe, as well as northern and central Asia. Of the at least 15 different types of ivy leaves, it is one of the more familiar plants to most people, being grown in gardens across the world.

Symbolism

Hedera helix has been associated with various symbolic meanings throughout history. Most often, it is seen as a symbol of friendship and fidelity. Most importantly, it is considered a symbol of eternal life due to its evergreen nature, even in winter, and its ability to bind and cling to surfaces.

Medicinal Uses

The ivy leaf has also served various purposes in traditional medicine, believed to have expectorant properties. Historically, Hedera helix has specifically found diverse applications, addressing medical matters ranging from digestive issues to general wound care. Presently, it is well-known as a natural remedy with firmly established medicinal properties.

ABOUT EA 575®

Not all ivy leaves are the same. Let's find more about the most studied Ivy leaf, EA 575®

EA 575® is not a typical ivy leaf extract.

Certain ivy leaf extracts are proven safe and effective in the treatment of respiratory diseases, but among them, EA 575® is the only ivy leaf extract that has been extensively studied and used for treatment1.

With over 65,000 patients having participated in clinical and post-marketing studies, EA 575® has demonstrated its high effectiveness and safety as an active ingredient.

ABOUT

DISCOVER EA 575®

The Most Studied Ivy Leaf Extract

Developed over 65 years ago

18 published clinical studies

Extensive global research involving 65,000+ participants

Learn more about its scientific research and health benefits

Discover

Comparison between EA 575® and other Ivy leaf extracts 2,3

  • EA 575® Ivy Leaf Extracts
  • Other Ivy Leaf Extracts
  • Higher Reduction of Bronchitis Severity Score  
  • Reduction of Bronchitis Severity Score  
  • Excellent Tolerability  
  • High Tolerability  
  • Most Controlled Clinical Studies  
  • Fewer Controlled Clinical Studies  
  • Proved Effective for More Than 65,000 Patients  
  • Proved Effective for Smaller Sample Size  
  • Produced with a Patented Procedure icon1  
  • Not Produced with a Patented Procedureicon2  
    1. Lang, C., Röttger-Lüer, P., & Staiger, C. (2015). A valuable option for the treatment of respiratory diseases: Review on the clinical evidence of the ivy leaves dry extract EA 575®. Planta Medica, 81(12/13), 968-974.https://doi.org/10.1055/s-0035-1545879
    2. Unkauf M, Friedrich M. Bronchitis bei Kindern – Klinische Studie mit Efeublätter-Trockenextrakt. Der Bayerische Internist 2000; 4: 1–4
    3. Cwientzek U, Ottillinger B, Arenberger P. Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomized study vs. an other ivy leaves extract. Phytomedicine 2011; 18: 1105– 1109
RESEARCH
RESEARCH

EA 575® IS BACKED BY SCIENCE

EA 575® ivy leaf extract is the very first natural ivy extract to obtain official Health Canada approval.

Also supported by an impressive array of 18 publications and involving a substantial studied population of over 65,000 patients4, this product stands as a reliable and evidence-based solution that improves respiratory function for patients.

4. Lang C, et al., Planta Med 2015;81:968-974. Supported by Engelhard Arzneimittel GmbH & Co. KG

MAIN DIFFERENCES

With the EA 575® extract being more effective against chronic bronchitis than the others. Here are the most recent statistics and results from clinical trials and scientific studies.

Lang et al., 20155

1066 school children (6-12 years) suffering from respiratory ailments

IMPROVEMENT
  • Improvement in symptoms such as coughing and breathing difficulties.
  • Relief in as quickly as 3.48 days

Study included Prospan, Prospan Drops and Prospan lozenges.*

Schaefer et al., 20196

209 adults (18-73 years) suffering from acute bronchitis

SIGNIFICANT IMPROVEMENT
  • Significant recovery of at least 50% in 7 days
  • 76.9% saw improvement in symptoms.

Study included Prospan Menthol.*

Fazio et al., 20097

9657 patients (including 5181 children) suffering from bronchitis (i.e., acute or chronic bronchial inflammatory disease)

IMPROVEMENT
  • 95% of the patients showed improvement or healed from their symptoms after 7 days.
  • 91% felt soothing and calming of chest.
  • 97% had good or very good tolerability.

Study included Prospan Menthol.*

5. Lang, C., Röttger-Lüer, P., & Staiger, C. (2015). A valuable option for the treatment of respiratory diseases: Review on the clinical evidence of the ivy leaves dry extract EA 575®. Planta Medica, 81 (12/13), 968-974. https://doi.org/10.1055/s-0035-1545879

6. Schaefer, A., Kehr, M., Giannetti, B., Bulitta, M., & Staiger, C. (2016). RCT to evaluate the efficacy and safety of ivy leaves cough liquid containing EA 575® in the treatment of acute cough. Planta Medica, 81 (S 01), S1-S381. https://doi.org/10.1055/s-0036-1597069

7. Fazio, S., Pouso, J., Dolinsky, D., Fernandez, A., Hernandez, M., Clavier, G., & Hecker, M. (2009). Tolerance, safety and efficacy of hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: A prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine, 16 (1), 17-24. https://doi.org/10.1016/j.phymed.2006.05.003

MECHANISM OF ACTIONS (MOA)

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EA 575® is also unique to help improve respiratory function in patients with bronchitis.

  • The EA 575® is an active ingredient from natural ivy leaf which liquefies the sticky mucus trapped in the air passages of the lungs.
  • It then acts as an expectorant, allowing the mucus to be coughed up more easily.
  • As the air passages relax and widen, you are able to breathe better and more comfortably.
air passages of the lungs
air passages of the lungs

WHY EA 575® IS A HIGH-QUALITY PRODUCT

EA 575® is manufactured in Europe to the highest pharmaceutical standards, guaranteeing trusted quality in every bottle.

The production process of EA 575® is rigorous, with strict quality controls and extensive testing at every stage. This ensures a consistently high-quality product for every batch being produced, providing adults and children with the desired health outcomes demonstrated in clinical trials8.

8. Lang C, et al., Planta Med 2015;81:968-974. Supported by Engelhard Arzneimittel GmbH & Co. KG
Plant material
  • Plant genetics
  • Plant age
  • Part of plant used
Growing & harvesting
  • Soil type & consistency
  • Location & climate
  • Growing time
  • Harvesting time & method
Extraction method & Manufacturing processes
  • Drying & storage
  • Extraction method
  • Extraction solvent